Cyanocobalamin vs. Methylcobalamin: The Truth
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Why is B12 important in nerve health?
Vitamin B12 is crucial for nerve health, as it helps prevent neuropathy by preserving the myelin sheath and enhancing nerve function. Additionally, individuals with diabetes on Metformin may require B12 supplementation due to the medication's interference with its absorption.
Methylcobalamin vs Cyanocobalamin? Which is better?
Cyanocobalamin and Methylcobalamin are two forms of vitamin B12, but they have key differences in structure, absorption, and function.
1. Absorption & Conversion
- Cyanocobalamin: Must be converted by the body into methylcobalamin and adenosylcobalamin before it becomes biologically active.
- Methylcobalamin: Already an active form of B12 and does not require conversion.
2. Effectiveness
- Cyanocobalamin: More stable and widely used in supplements due to its long shelf life.
- Methylcobalamin: More readily utilized by the body, especially for neurological and cognitive functions.
3. Bioavailability
- Cyanocobalamin: Less bioavailable because the body must convert it.
- Methylcobalamin: More bioavailable and directly used in cellular processes.
4. Safety & Cyanide Content
- Cyanocobalamin: Contains a small amount of cyanide, which is generally harmless but may be a concern for people with kidney disease.
- Methylcobalamin: Does not contain cyanide, making it a preferred choice for those with impaired detoxification.
5. Medical Uses
- Cyanocobalamin: Used in general B12 deficiency treatment due to its cost-effectiveness.
- Methylcobalamin: Often recommended for neurological conditions, peripheral neuropathy, and cognitive health.
6. Availability & Cost
- Cyanocobalamin: Cheaper and more common in supplements.
- Methylcobalamin: More expensive but preferred for specific health benefits.
Which One to Choose?
For general B12 deficiency → Cyanocobalamin (affordable and effective).
For nerve health, brain function, and methylation support → Methylcobalamin.
For people with kidney issues or difficulty converting B12 → Methylcobalamin.
What kind of B12 does NerveReverse use?

NerveReverse features 2 mg (2,000 mcg) of Methylcobalamin per daily serving, enhancing bioavailability, ensuring a superior safety profile, and yielding improved outcomes for individuals experiencing neuropathy.